Last week I utilized EBI’s database to research the pathologies associated with pirin in the human body. This week I will continue to use EBI’s database, specifically VarSite, a portion of the EBI database concerned with cataloging disease-associated variants in humans (Laskowski, Stephenson, Sillitoe, et al., 2020). I will be using this database to further research pirin-associated pathologies as well as its catalytic activity and tissue specificity. When searching for pirin on the VarSite database I was immediately given pirin’s ID number ( O0065 ), its VarSite ID number ( PIR_Human ), as well as a brief description of pirin’s tissue specificity and tissue related pathology that reads as follows “[Pirin is] highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level [ sic ] of expres sion in heart and liver.” This description fits with my research...
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